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PMID: 7850202 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Origin and molecular epidemiology of penicillin-binding-protein-mediated resistance to beta-lactam antibiotics.

Trends in microbiology ·Vol. 2 ·No. 10 ·1994-10-00 ·Pages 361-6

Dowson CG, Coffey TJ, Spratt BG

Abstract

Resistance to beta-lactam antibiotics in some naturally transformable bacterial pathogens has arisen by interspecies recombinational events that have generated hybrid penicillin-binding proteins with reduced affinity for the antibiotics. This type of resistance is of particular concern in pneumococci, in which it is increasing worldwide.

Related Genes

pbp

MeSH Terms

Bacterial Proteins Carrier Proteins/genetics Clone Cells Gene Transfer Techniques Hexosyltransferases Muramoylpentapeptide Carboxypeptidase/genetics Penicillin Resistance/genetics Penicillin-Binding Proteins Peptidyl Transferases Pneumococcal Infections/epidemiology Recombination, Genetic Streptococcus pneumoniae/genetics beta-Lactam Resistance/genetics

Chemicals

Bacterial Proteins Carrier Proteins Penicillin-Binding Proteins Peptidyl Transferases Hexosyltransferases Muramoylpentapeptide Carboxypeptidase

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Dowson C G

Microbial Genetics Group, School of Biological Sciences, University of Sussex, Brighton, UK.

Coffey T J

Spratt B G

Article Info

Journal

Trends in microbiology

Abbr.

Trends Microbiol

ISSN

0966-842X

DOI

10.1016/0966-842x(94)90612-2

Published

1994-10-00

Pages

361-6

Language

English

Region

England

NLM ID

9310916

Subset

External Links

PubMed source DOI: 10.1016/0966-842x(94)90612-2 View journal details

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Origin and molecular epidemiology of penicillin-binding-protein-mediated resistance to beta-lactam antibiotics.

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