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PMID: 7884921 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Varicella-zoster virus (VZV) transcription during latency in human ganglia: prevalence of VZV gene 21 transcripts in latently infected human ganglia.

Journal of virology ·Vol. 69 ·No. 4 ·1995-04-00 ·Pages 2674-8

Cohrs RJ, Barbour MB, Mahalingam R, Wellish M, Gilden DH

Abstract

Reverse transcriptase-linked PCR was used to determine the prevalence of varicella-zoster virus (VZV) gene 21 transcription in latently infected human ganglia. Under conditions wherein reverse transcriptase-linked PCR detected > or = 1,000 transcripts, VZV gene 21 RNA, but not VZV gene 40 RNA, was found in ganglia but not other tissues from five of seven humans.

MeSH Terms

Base Sequence DNA Primers Ganglia/virology Herpesvirus 3, Human/genetics Humans Molecular Sequence Data RNA, Messenger/genetics,metabolism Transcription, Genetic Viral Proteins/genetics Virus Latency

Chemicals

DNA Primers RNA, Messenger Viral Proteins

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Cohrs R J

Department of Neurology, University of Colorado Health Sciences Center, Denver 80262.

Barbour M B

Mahalingam R

Wellish M

Gilden D H

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24 references, click to expand

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Article Info

Journal

Journal of virology

Abbr.

J Virol

ISSN

0022-538X

DOI

10.1128/JVI.69.4.2674-2678.1995

Published

1995-04-00

Pages

2674-8

Language

English

Region

United States

NLM ID

0113724

PMCID

PMC188953

Subset

Grants

NIA NIH HHS · AG 06127 · United States

NINDS NIH HHS · NS 07321 · United States

NINDS NIH HHS · NS 32623 · United States

External Links

PubMed source DOI: 10.1128/JVI.69.4.2674-2678.1995 PMC Full Text View journal details

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Varicella-zoster virus (VZV) transcription during latency in human ganglia: prevalence of VZV gene 21 transcripts in latently infected human ganglia.

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