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PMID: 78954 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Immunological studies of T-cell receptors. I. Specifically induced resistance to graft-versus-host disease in rats mediated by host T-cell immunity to alloreactive parental T cells.

The Journal of experimental medicine ·Vol. 148 ·No. 1 ·1978-07-01 ·Pages 103-14

Bellgrau D, Wilson DB

Abstract

The present studies extend our previous efforts to understand the immunological basis of specifically induced graft-versus-host (GVH) resistance in F1 hybrid rats. Immunization of F1 rats with alloreactive T-cell populations of parental strain origin induces a host-mediated T-cell response which is specific for anti-major hostocompatibility complex receptors on parental T cells. This protective immunity is rapid in onset and once induced, it provides a highly effective, specific resistance to lethal GVH disease which is radioresistant and can be adoptively transferred to syngeneic recipients.

MeSH Terms

Animals Binding Sites, Antibody Epitopes Female Graft vs Host Disease/immunology Histocompatibility Histocompatibility Antigens Hybridization, Genetic Immunity, Cellular/radiation effects Lymphocyte Transfusion Male Rats T-Lymphocytes/immunology Transplantation, Homologous

Chemicals

Epitopes Histocompatibility Antigens

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Bellgrau D

Wilson D B

References (24)

24 references, click to expand

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Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.148.1.103

Published

1978-07-01

Pages

103-14

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2184917

Subset

External Links

PubMed source DOI: 10.1084/jem.148.1.103 PMC Full Text View journal details

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Immunological studies of T-cell receptors. I. Specifically induced resistance to graft-versus-host disease in rats mediated by host T-cell immunity to alloreactive parental T cells.

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