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PMID: 7898468 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

Cyclic ADP-ribose: a calcium mobilizing metabolite of NAD+.

Molecular and cellular biochemistry ·Vol. 138 ·No. 1-2 ·1994-09-00 ·Pages 229-35

Lee HC

Abstract

Mobilization of Ca+2 from intracellular stores is a signalling mechanism that is of fundamental importance to many cellular processes. It is mediated by two major mechanisms, the inositol 1,4,5-trisphosphate pathway and the Ca+2-induced Ca+2 release process. A naturally occurring metabolite of NAD+ called cyclic ADP-ribose has been discovered recently and shown to be as effective as inositol 1,4,5-trisphosphate in mobilizing Ca+2 stores in sea urchin eggs, a marine invertebrate cell, as well as several mammalian cells. This article reviews the accumulating evidence that indicates cyclic ADP-ribose may function as a physiological regulator of the Ca+2-induced Ca+2 release process and the current knowledge about its receptor as well as the enzymes involved in its metabolism.

MeSH Terms
ADP-ribosyl Cyclase ADP-ribosyl Cyclase 1 Adenosine Diphosphate Ribose/analogs & derivatives,antagonists & inhibitors,physiology Animals Antigens, CD Antigens, Differentiation/metabolism Calcium/metabolism Cyclic ADP-Ribose Humans Membrane Glycoproteins Molecular Structure N-Glycosyl Hydrolases/metabolism NAD/metabolism Receptors, Cell Surface/metabolism
Chemicals
Antigens, CD Antigens, Differentiation Membrane Glycoproteins Receptors, Cell Surface cyclic ADP-ribose receptor NAD Cyclic ADP-Ribose Adenosine Diphosphate Ribose N-Glycosyl Hydrolases ADP-ribosyl Cyclase CD38 protein, human ADP-ribosyl Cyclase 1 Calcium
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Lee H C
Department of Physiology, Lyon Laboratory, University of Minnesota, Minneapolis 55455.
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36 references, click to expand
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Article Info
Journal
Molecular and cellular biochemistry
Abbr.
Mol Cell Biochem
ISSN
0300-8177
DOI
10.1007/BF00928466
Published
1994-09-00
Pages
229-35
Language
English
Region
Netherlands
NLM ID
0364456
Subset
IM
Grants
NICHD NIH HHS · HD17484 · United States
External Links
PubMed source DOI: 10.1007/BF00928466 View journal details
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