Endogenous opioid peptides in neurons of the human brain.

Lancet (London, England) ·Vol. 2 ·No. 8084 ·1978-08-05 ·Pages 291-3

Cuello AC

Abstract

Immunoreactive leucine-encephalin has been found in nerve terminals and cell bodies of neurons in the human brain. The most intense reaction was found in the globus pallidus, followed by the spinal nucleus of the trigeminal nerve. These observations suggest that in man endogenous opioid substances may play an important part in neurotransmission in areas of the central nervous system related to pain and locomotor activity.

MeSH Terms

Animals Antigens Brain/cytology Brain Chemistry Endorphins/isolation & purification Enkephalins/isolation & purification Fluorescent Antibody Technique Globus Pallidus/analysis Humans Microscopy, Fluorescence Nerve Endings/analysis Neurons/analysis Putamen/analysis Rabbits Rats Receptors, Opioid/isolation & purification Synaptic Transmission Trigeminal Nerve/analysis

Chemicals

Antigens Endorphins Enkephalins Receptors, Opioid

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Cuello A C

Article Info

Journal

Lancet (London, England)

Abbr.

Lancet

ISSN

0140-6736

DOI

10.1016/s0140-6736(78)91692-6

Published

1978-08-05

Pages

291-3

Language

English

Region

England

NLM ID

2985213R

Subset

External Links

PubMed source DOI: 10.1016/s0140-6736(78)91692-6 View journal details

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Endogenous opioid peptides in neurons of the human brain.

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