Indirect method for assessing the penetration of beta-lactamase-nonsusceptible penicillins and cephalosporins in Escherichia coli strains.

Antimicrobial agents and chemotherapy ·Vol. 10 ·No. 2 ·1976-08-00 ·Pages 215-8

Richmond MH, Clark DC, Wotton S

Abstract

Escherichia coli UB1005 and two mutants of this strain (DC2 and DC3) have been used to assess indirectly the relative ability of various beta-lactam antibiotics to penetrate the outer layers of E. coli. Benzylpenicillin, ampicillin, methicillin, cloxacillin, cephaloridine, cephalothin, and cephalexin have been examined. The results confirm those obtained with other methods and show that, among the compounds studied here, cephalosporins seem to penetrate more readily than penicillins.

MeSH Terms

Cephalosporinase/metabolism Cephalosporins/metabolism Escherichia coli/enzymology,metabolism Methods Mutation Penicillinase/metabolism Penicillins/metabolism

Chemicals

Cephalosporins Penicillins Cephalosporinase Penicillinase

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Richmond M H

Clark D C

Wotton S

References (13)

13 references, click to expand

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Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.10.2.215

Published

1976-08-00

Pages

215-8

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC429723

Subset

External Links

PubMed source DOI: 10.1128/AAC.10.2.215 PMC Full Text View journal details

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Indirect method for assessing the penetration of beta-lactamase-nonsusceptible penicillins and cephalosporins in Escherichia coli strains.

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