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PMID: 7916708 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Isolation of rat cDNA clones coding for the autoantigen SS-B/La: detection of species-specific variations.

Gene ·Vol. 126 ·No. 2 ·1993-04-30 ·Pages 265-8

Semsei I, Tröster H, Bartsch H, Schwemmle M, Igloi GL, Bachmann M

Abstract

Clones of cDNA coding for the autoantigen La (or SS-B) were isolated from a library made from rat liver. A comparison of the rat La cDNA (encoding from nt 38 to 1281 for rat La protein) with the sequences known for human and bovine La protein resulted in the identification of species-specific inserts. The inserts seem to be the result of multiplication of flanking sequences during evolution. In addition to these variations, we observed that rat La cDNAs exhibit non-canonical polyadenylation sites. Finally, a databank search resulted in the identification of a DNA sequence originally termed as TAG or TSG20X (GenBank accession No. X61893) which represents the C terminus of mouse La/SS-B protein.

MeSH Terms
Amino Acid Sequence Animals Autoantigens/genetics Base Sequence Cloning, Molecular DNA/isolation & purification Genetic Variation Humans Introns Molecular Sequence Data Rats Ribonucleoproteins/genetics Sequence Homology, Nucleic Acid Species Specificity
Chemicals
Autoantigens Ribonucleoproteins SS-B antigen DNA
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Semsei I
Institut für Physiologische Chemie, Universität, Mainz, Germany.
Tröster H
Bartsch H
Schwemmle M
Igloi G L
Bachmann M
Article Info
Journal
Gene
Abbr.
Gene
ISSN
0378-1119
DOI
10.1016/0378-1119(93)90378-g
Published
1993-04-30
Pages
265-8
Language
English
Region
Netherlands
NLM ID
7706761
Subset
IM
Databases
GENBANK
D12906, D12907, L03653, L03654, L07631, L07632, S59892, S59893, X13697, X13698, X54209, X61893, X67859, X67963
External Links
PubMed source DOI: 10.1016/0378-1119(93)90378-g View journal details
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