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PMID: 7922327 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Implications of the SNARE hypothesis for intracellular membrane topology and dynamics.

Current biology : CB ·Vol. 4 ·No. 3 ·1994-03-01 ·Pages 220-33

Rothman JE, Warren G

Abstract

The SNARE hypothesis provides a mechanism for the specific docking and fusion of transport vesicles with their target membranes. A simple extension of the hypothesis can explain many cellular processes, including the stacking of Golgi cisternae, retrograde transport and homotypic fusion; it can also explain the morphology of intracellular membranes and their dynamics during mitosis.

MeSH Terms

Animals Carrier Proteins/physiology GTP-Binding Proteins/physiology Golgi Apparatus/physiology Intracellular Membranes/physiology,ultrastructure Membrane Fusion/physiology Membrane Proteins/physiology Mitosis/physiology Models, Biological Nerve Tissue Proteins/physiology R-SNARE Proteins Soluble N-Ethylmaleimide-Sensitive Factor Attachment Proteins Vesicular Transport Proteins

Chemicals

Carrier Proteins Membrane Proteins Nerve Tissue Proteins R-SNARE Proteins Soluble N-Ethylmaleimide-Sensitive Factor Attachment Proteins Vesicular Transport Proteins GTP-Binding Proteins

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Rothman J E

Cellular Biochemistry and Biophysics Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021.

Warren G

Article Info

Journal

Current biology : CB

Abbr.

Curr Biol

ISSN

0960-9822

DOI

10.1016/s0960-9822(00)00051-8

Published

1994-03-01

Pages

220-33

Language

English

Region

England

NLM ID

9107782

Subset

External Links

PubMed source DOI: 10.1016/s0960-9822(00)00051-8 View journal details

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Implications of the SNARE hypothesis for intracellular membrane topology and dynamics.

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