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PMID: 795576 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Leukocyte migration inhibitory factor (LMIF) profile in primary and secondary immunodeficiency disease.

Clinical and experimental immunology ·Vol. 26 ·No. 3 ·1976-12-00 ·Pages 505-10

Górski AJ, Dupont B, Hansen JA, O'Reilly R, Smithwick E, Górska R, Good RA

Abstract

Lymphocytes from patients with primary and secondary immunodeficiency disease were tested for capacity to produce LMIF after mitogen and antigen stimulation as well as for ability to stimulate and respond in unidirectional MLC-LMIF assay. Different patterns of immune abnormality in vitro were detectable when Con A and Candida albicans antigen were used. In addition, significant abnormalities in LMIF responding and stimulatory capacity were demonstrated in patients with Hodgkin's disease. LMIF production after stimulation with different agents allows for a better characterization of cellular defects in immunodeficiency disease.

MeSH Terms
Antigens, Fungal Humans Immunologic Deficiency Syndromes/immunology Lymphocyte Activation Lymphocytes/immunology Macrophage Migration-Inhibitory Factors/analysis Mitogens
Chemicals
Antigens, Fungal Macrophage Migration-Inhibitory Factors Mitogens
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Górski A J
Dupont B
Hansen J A
O'Reilly R
Smithwick E
Górska R
Good R A
References (14)
14 references, click to expand
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Article Info
Journal
Clinical and experimental immunology
Abbr.
Clin Exp Immunol
ISSN
0009-9104
Published
1976-12-00
Pages
505-10
Language
English
Region
England
NLM ID
0057202
PMCID
PMC1540992
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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