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PMID: 7958776 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Resistance to amphotericin B associated with defective sterol delta 8-->7 isomerase in a Cryptococcus neoformans strain from an AIDS patient.

FEMS microbiology letters ·Vol. 122 ·No. 1-2 ·1994-09-15 ·Pages 39-42

Kelly SL, Lamb DC, Taylor M, Corran AJ, Baldwin BC, Powderly WG

Abstract

Two Cryptococcus neoformans strains isolated from an AIDS patient were investigated, a pretreatment isolate (CN1) and a second isolate (CN3) following failure of fluconazole and amphotericin B treatment. No difference in fluconazole sensitivity, but relative resistance to amphotericin B was observed for CN3. The sterol composition of CN3 indicated a defect in sterol delta 8-->7 isomerase in this strain and depletion of ergosterol, the major sterol of the CN1.

MeSH Terms

Acquired Immunodeficiency Syndrome/microbiology Amphotericin B/pharmacology Cryptococcus neoformans/drug effects,enzymology Drug Resistance, Microbial/genetics Humans Microbial Sensitivity Tests Mutation/genetics Steroid Isomerases/genetics

Chemicals

Amphotericin B Steroid Isomerases

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Kelly S L

Krebs Institute for Biomolecular Research, Department of Molecular Biology and Biotechnology, Sheffield University, UK.

Lamb D C

Taylor M

Corran A J

Baldwin B C

Powderly W G

Article Info

Journal

FEMS microbiology letters

Abbr.

FEMS Microbiol Lett

ISSN

0378-1097

DOI

10.1111/j.1574-6968.1994.tb07140.x

Published

1994-09-15

Pages

39-42

Language

English

Region

England

NLM ID

7705721

Subset

Grants

Wellcome Trust · United Kingdom

External Links

PubMed source DOI: 10.1111/j.1574-6968.1994.tb07140.x View journal details

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Resistance to amphotericin B associated with defective sterol delta 8-->7 isomerase in a Cryptococcus neoformans strain from an AIDS patient.

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