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PMID: 799243 Published · ppublish English Journal Article

A virus-specified mechanism for the prevention of multiple infection--T7- and T3-mutual and superinfection exclusion.

Molecular & general genetics : MGG ·Vol. 149 ·No. 3 ·1976-12-22 ·Pages 243-9

Hirsch-Kauffmann M, Pfenning-Yeh M, Ponta H, Herrlich P, Schweiger M

Abstract

Co- and superinfection of cells with T3/T7 result in exclusion (mutual or superinfection exclusion). The exclusion mechanism is also directed against homologous (or identical) virus. Exclusion is established after the adsorption but before the genome becomes available for gene expression or replication, that is only one virus per cell develops. The exclusion is triggered by a constituant of the viral particle. An early T7 gene (M gene) (Schweiger et al., 1975) is essential for the formation of exclusion competent virions.

MeSH Terms
Bacterial Proteins/biosynthesis Coliphages/metabolism DNA Replication Electrophoresis, Polyacrylamide Gel Escherichia coli/metabolism Genes Kinetics Polynucleotide Ligases/metabolism Protein Biosynthesis Species Specificity Viral Proteins/biosynthesis Virus Replication
Chemicals
Bacterial Proteins Viral Proteins Polynucleotide Ligases
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Hirsch-Kauffmann M
Pfenning-Yeh M
Ponta H
Herrlich P
Schweiger M
References (18)
18 references, click to expand
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Article Info
Journal
Molecular & general genetics : MGG
Abbr.
Mol Gen Genet
ISSN
0026-8925
Published
1976-12-22
Pages
243-9
Language
English
Region
Germany
NLM ID
0125036
Subset
IM
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