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PMID: 8013492 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Cluster of an erythromycin-resistant variant of the Spanish multiply resistant 23F clone of Streptococcus pneumoniae in South Africa.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology ·Vol. 13 ·No. 2 ·1994-02-00 ·Pages 171-4

Klugman KP, Coffey TJ, Smith A, Wasas A, Meyers M, Spratt BG

Abstract

A multiply resistant serotype 23F pneumococcus was cultured from a 3-year-old child with otitis media and five carriers at the child's day-care centre in South Africa. Attempts to eradicate carriage with mupirocin failed. The strains were identical to the Spanish clone of multiply resistant pneumococci by serotype, antimicrobial susceptibility pattern, restriction analysis of the penicillin-binding protein 1A, 2B and 2X genes and by multilocus enzyme electrophoresis. The data suggest that this clone has acquired erythromycin resistance. A possible link between the index case and residence of a family member in Spain was found.

MeSH Terms

Adult Carrier State/drug therapy,epidemiology,microbiology Child Child, Preschool Cluster Analysis DNA Fingerprinting DNA, Bacterial/genetics Drug Resistance, Microbial Erythromycin Female Humans Infant Mupirocin/therapeutic use Otitis Media/microbiology Pneumococcal Infections/epidemiology,genetics,microbiology South Africa/epidemiology Spain/epidemiology Species Specificity Streptococcus pneumoniae/genetics,isolation & purification

Chemicals

DNA, Bacterial Erythromycin Mupirocin

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Klugman K P

Department of Medical Microbiology, University of the Witwatersrand, Johannesburg, South Africa.

Coffey T J

Smith A

Wasas A

Meyers M

Spratt B G

References (9)

9 references, click to expand

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Article Info

Journal

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

Abbr.

Eur J Clin Microbiol Infect Dis

ISSN

0934-9723

DOI

10.1007/BF01982193

Published

1994-02-00

Pages

171-4

Language

English

Region

Germany

NLM ID

8804297

Subset

Grants

Wellcome Trust · United Kingdom

External Links

PubMed source DOI: 10.1007/BF01982193 View journal details

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Cluster of an erythromycin-resistant variant of the Spanish multiply resistant 23F clone of Streptococcus pneumoniae in South Africa.

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