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PMID: 8016 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Marrow transplantation in treatment of children with aplastic anaemia or acute leukaemia.

Archives of disease in childhood ·Vol. 51 ·No. 6 ·1976-06-00 ·Pages 403-10

Johnson FL, Hartmann JR, Thomas ED, Chard RL, Hersman JA, Buckner CD, Clift RA, Storb R

Abstract

Seventy-six patients, aged 2 to 17 years, were treated with bone marrow transplantation for severe aplastic anaemia or acute leukaemia refractory to conventional therapy. 16 of the 22 patients (73%) who received marrow transplantations for aplastic anaemia are surviving, 12 of these for over one year. In acute leukaemia, using preparation with cyclophosphamide and total body irradiation, 8 of 33 patients (24%) receiving allogeneic and 5 of 8 (63%) receiving syngeneic transplantations are continuing in remission from 3 months to beyond 2 years. The longest continuing remission off therapy is now over 4 1/2 years after preparation with total body irradiation. The major causes of failure remain graft-versus-host disease, infection, graft rejection (aplastic anaemia), and leukaemic relapse.

MeSH Terms
Adolescent Anemia, Aplastic/therapy Bone Marrow Cells Bone Marrow Transplantation Child Child, Preschool Female Graft Rejection Graft vs Host Reaction Humans Leukemia, Lymphoid/radiotherapy,therapy Leukemia, Myeloid, Acute/radiotherapy,therapy Male Remission, Spontaneous Transplantation, Homologous
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Johnson F L
Hartmann J R
Thomas E D
Chard R L
Hersman J A
Buckner C D
Clift R A
Storb R
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18 references, click to expand
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Article Info
Journal
Archives of disease in childhood
Abbr.
Arch Dis Child
ISSN
1468-2044
DOI
10.1136/adc.51.6.403
Published
1976-06-00
Pages
403-10
Language
English
Region
England
NLM ID
0372434
PMCID
PMC1546004
Subset
IM
External Links
PubMed source DOI: 10.1136/adc.51.6.403 PMC Full Text View journal details
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