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PMID: 8027316 Published · ppublish English Journal Article

Ribotyping patterns and emergence of metronidazole resistance in paired clinical samples of Helicobacter pylori.

Journal of clinical microbiology ·Vol. 32 ·No. 4 ·1994-04-00 ·Pages 1079-82

Rautelin H, Tee W, Seppälä K, Kosunen TU

Abstract

Metronidazole-susceptible pretreatment isolates and metronidazole-resistant posttreatment isolates of Helicobacter pylori from 11 patients before and after unsuccessful triple therapy consisting of metronidazole, amoxicillin, and colloidal bismuth subcitrate were studied. Ribotyping (rRNA gene restriction pattern analysis) of the isolates demonstrated that all patients except one had identical digest patterns for pre- and posttreatment isolates.

MeSH Terms
Amoxicillin/administration & dosage Anti-Ulcer Agents/administration & dosage DNA, Bacterial/genetics DNA, Ribosomal/genetics Drug Resistance, Microbial/genetics Drug Therapy, Combination Gastritis/drug therapy,microbiology Helicobacter Infections/drug therapy,microbiology Helicobacter pylori/drug effects,genetics,isolation & purification Humans Metronidazole/administration & dosage,pharmacology Organometallic Compounds/administration & dosage Peptic Ulcer/drug therapy,microbiology
Chemicals
Anti-Ulcer Agents DNA, Bacterial DNA, Ribosomal Organometallic Compounds Metronidazole Amoxicillin bismuth tripotassium dicitrate
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Rautelin H
Department of Bacteriology and Immunology, University of Helsinki, Finland.
Tee W
Seppälä K
Kosunen T U
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20 references, click to expand
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Article Info
Journal
Journal of clinical microbiology
Abbr.
J Clin Microbiol
ISSN
0095-1137
DOI
10.1128/jcm.32.4.1079-1082.1994
Published
1994-04-00
Pages
1079-82
Language
English
Region
United States
NLM ID
7505564
PMCID
PMC267189
Subset
IM
External Links
PubMed source DOI: 10.1128/jcm.32.4.1079-1082.1994 PMC Full Text View journal details
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