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PMID: 803528 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S.

Similar idiotypic specificity for the membrane IgD and IgM of human B lymphocytes.

Journal of immunology (Baltimore, Md. : 1950) ·Vol. 114 ·No. 1 Pt 1 ·1975-01-00 ·Pages 250-2

Fu SM, Winchester RJ, Kunkel HG

Abstract

Certain cases of chronic lymphocytic leukemia possess monoclonal bands in the serum. Idiotypic antibodies to the isolated IgM protein of one such case demonstrated that the leukemic lymphocytes carried the identical specificity on their lymphocytes. Both the lymphocyte IgM and the IgD possessed this same specificity. This was demonstrated best through the use of rhodamine-conjugated Fab fragments of IgM- and IgD-specific antisera which were both capped by the idiotypic antiserum.

MeSH Terms

Animals Antibody Specificity B-Lymphocytes/immunology Binding Sites, Antibody Cell Membrane/immunology Fluorescent Antibody Technique Hemagglutination Inhibition Tests Hemagglutination Tests Humans Immune Sera Immunoglobulin D Immunoglobulin Fab Fragments Immunoglobulin Heavy Chains Immunoglobulin M Immunoglobulin kappa-Chains Immunoglobulin lambda-Chains Leukemia, Lymphoid/immunology Rabbits/immunology

Chemicals

Immune Sera Immunoglobulin D Immunoglobulin Fab Fragments Immunoglobulin Heavy Chains Immunoglobulin M Immunoglobulin kappa-Chains Immunoglobulin lambda-Chains

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Fu S M

Winchester R J

Kunkel H G

Article Info

Journal

Journal of immunology (Baltimore, Md. : 1950)

Abbr.

J Immunol

ISSN

0022-1767

Published

1975-01-00

Pages

250-2

Language

English

Region

United States

NLM ID

2985117R

Subset

External Links

PubMed source View journal details

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Similar idiotypic specificity for the membrane IgD and IgM of human B lymphocytes.

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