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PMID: 8037697 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Highly sensitive control of transcriptional activity by factor heterodimerization.

The Biochemical journal ·Vol. 301 ( Pt 1) ·1994-07-01 ·Pages 9-12

Swillens S, Pirson I

Abstract

Several molecular mechanisms have been proposed to explain highly sensitive controls of cellular functions by effector molecules. Here we study an equilibrium model describing the regulation of transcriptional activity through the heterodimerization of transcription factors. We demonstrate that this model involves a new type of biochemical control which accounts for a very high sensitivity.

MeSH Terms

Basic-Leucine Zipper Transcription Factors Binding Sites DNA/metabolism DNA-Binding Proteins/chemistry,genetics,metabolism Models, Biological Protein Conformation Proto-Oncogene Proteins c-myc/chemistry,genetics,metabolism Repressor Proteins Transcription Factors/chemistry,genetics,metabolism Transcription, Genetic

Chemicals

Basic-Leucine Zipper Transcription Factors DNA-Binding Proteins Myc associated factor X Proto-Oncogene Proteins c-myc Repressor Proteins Transcription Factors DNA

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Swillens S

Institut de Recherche Interdisciplinaire, Faculté de Médecine, Université Libre de Bruxelles, Belgium.

Pirson I

References (9)

9 references, click to expand

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Myc and Max associate in vivo.
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Mad: a heterodimeric partner for Max that antagonizes Myc transcriptional activity.
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Identification of casein kinase II phosphorylation sites in Max: effects on DNA-binding kinetics of Max homo- and Myc/Max heterodimers.
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Expression of mad, mxi1, max and c-myc during induced differentiation of hematopoietic cells: opposite regulation of mad and c-myc.
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Article Info

Journal

The Biochemical journal

Abbr.

Biochem J

ISSN

0264-6021

DOI

10.1042/bj3010009

Published

1994-07-01

Pages

9-12

Language

English

Region

England

NLM ID

2984726R

PMCID

PMC1137134

Subset

External Links

PubMed source DOI: 10.1042/bj3010009 PMC Full Text View journal details

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