Studies on the mechanism of macrophage-mediated cytotoxicity.

International archives of allergy and applied immunology ·Vol. 48 ·No. 2 ·1975-00-00 ·Pages 182-91

Ziegler FG, Lohmann-Matthes ML, Fischer H

Abstract

MCF is a product of sensitized T lymphocytes, which is actively synthesized and secreted when lymphocytes are incubated with the appropriate target cells. The process of macrophage activation leading to cytotoxicity needs a period of 24h. Macrophage-mediated cytotoxicity is restricted to the specific target cell. B cell antibody does not seem to be involved. The reaction cannot be inhibited by rabbit antimouse immunoglobulin. However, various conditions, which may interfere with this specificity, are discussed.

MeSH Terms

Absorption Animals Antibody Specificity Ascitic Fluid/cytology Cell Fractionation Cells, Cultured Chromium Radioisotopes Cytotoxicity Tests, Immunologic Female Fibroblasts Immune Sera Kinetics Lymphoma/immunology Macrophages/immunology Mast-Cell Sarcoma/immunology Mice Mice, Inbred C3H Mice, Inbred C57BL Molecular Weight Rabbits/immunology Spleen/cytology T-Lymphocytes/immunology Trypsin

Chemicals

Chromium Radioisotopes Immune Sera Trypsin

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Ziegler F G

Lohmann-Matthes M L

Fischer H

Article Info

Journal

International archives of allergy and applied immunology

Abbr.

Int Arch Allergy Appl Immunol

ISSN

0020-5915

DOI

10.1159/000231304

Published

1975-00-00

Pages

182-91

Language

English

Region

Switzerland

NLM ID

0404561

Subset

External Links

PubMed source DOI: 10.1159/000231304

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