Influence of tubercle aggregate size on severity of adjuvant arthritis in the rat.

Annals of the rheumatic diseases ·Vol. 34 ·No. 1 ·1975-02-00 ·Pages 49-53

Liyanage SP, Currey HL, Vernon-Roberts B

Abstract

Incorporation into Freund's complete adjuvant of tuberculous aggregates smaller than 90 mum in size is essential to produce adjuvant arthritis in the rat, and this correlates with a significantly greater degree of cell-mediated immunity to tuberculous antigens produced by small aggregates (smaller than 90 mum), when compared with large (larger than 90 mum) aggregates. This requirement for small aggregates to render Freund's complete adjuvant arthritogenic is not paralleled by detectable differences in antimycobacterial humoral antibody production nor by a size-dependent requirement for a conventional adjuvant effect.

MeSH Terms

Animals Antigens, Bacterial Arthritis, Rheumatoid/immunology Cell Aggregation Fluorescent Antibody Technique Freund's Adjuvant Hemagglutination Tests Immunity, Cellular Injections, Intradermal Lymphocyte Activation Lymphocytes/immunology Macrophage Migration-Inhibitory Factors Macrophages/immunology Mycobacterium tuberculosis/cytology Rats Serum Albumin Skin Tests Ultracentrifugation

Chemicals

Antigens, Bacterial Macrophage Migration-Inhibitory Factors Serum Albumin Freund's Adjuvant

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Liyanage S P

Currey H L

Vernon-Roberts B

References (8)

8 references, click to expand

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Suppression of experimentally induced polyarthritis in the rat by heterologous anti-lymphocyte serum.
Lancet. 1966 Oct 22;2(7469):889-91 PMID: 4162441
Inhibition of macrophage migration by a proteoglycan extracted from Kurloff cells of the guinea-pig.
Int Arch Allergy Appl Immunol. 1972;43(6):813-25 PMID: 4349750
Competence of thoracic duct cells in the transfer of adjuvant disease and delayed hypersensitivity. Evidence that mycobacterial components are required for the successful transfer of the disease.
Cell Immunol. 1972 Jan;3(1):78-87 PMID: 4621537
T and B cells in the blood and synovial fluid of rheumatoid patients.
Ann Rheum Dis. 1974 Sep;33(5):430-4 PMID: 4607817
Immunogenicity and arthritogenicity in the rat of an antigen from Mycobacterium tuberculosis wax D.
J Immunol. 1973 Aug;111(2):599-608 PMID: 4197988
Antibody to mycobacterial antigens in adjuvant arthritis (AA). I. Relationship to disease and delayed hypersensitivity.
Arthritis Rheum. 1972 May-Jun;15(3):283-92 PMID: 5031613
Lymphocyte activation. I. Response of T and B lymphocytes to phytomitogens.
Clin Exp Immunol. 1971 Oct;9(4):483-98 PMID: 4941661

Article Info

Journal

Annals of the rheumatic diseases

Abbr.

Ann Rheum Dis

ISSN

0003-4967

DOI

10.1136/ard.34.1.49

Published

1975-02-00

Pages

49-53

Language

English

Region

England

NLM ID

0372355

PMCID

PMC1006344

Subset

External Links

PubMed source DOI: 10.1136/ard.34.1.49 PMC Full Text View journal details

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Influence of tubercle aggregate size on severity of adjuvant arthritis in the rat.

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