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PMID: 8056072 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Inter-subject variability of cerebral activations in acquiring a motor skill: a study with positron emission tomography.

Experimental brain research ·Vol. 98 ·No. 3 ·1994-00-00 ·Pages 523-34

Schlaug G, Knorr U, Seitz R

Abstract

Cerebral structures activated during sequential right-hand finger movements were mapped with regional cerebral blood flow (rCBF) measurements by positron emission tomography (PET) in individual subjects. Nine healthy volunteers were examined twice; after initial learning and after practicing the finger movement sequence for more than 1 h. Task-specific activation sites were identified by statistical distributions of maximal activity and region size in rCBF subtraction images. A consistent task-specific activation in all nine subjects was detected in the contralateral sensorimotor cortex at an average movement rate of 3.2 Hz reached after practice. This corresponded to a significant increase of the mean rCBF in the left primary sensorimotor cortex in spatially standardised and averaged PET images. Additional task-specific activation sites detected by individual analysis were found in the lateral and medial premotor, parietal, and cingulate areas, and in subcortical structures including the basal ganglia of both cerebral hemispheres. These activations showed no or little spatial overlap from subject to subject, thus being obscured in the analysis of pooled data. The observed activity patterns were related to movement rate and accuracy in individual subjects. It is suggested that the rCBF changes associated with acquisition of a motor skill in individual humans may correspond to plasticity of sensorimotor representations reported in monkeys.

MeSH Terms
Adult Brain/diagnostic imaging,physiology Brain Mapping Cerebrovascular Circulation Humans Learning/physiology Male Motor Activity/physiology Observer Variation Tomography, Emission-Computed
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Schlaug G
Department of Neurology, Heinrich-Heine-University, Düsseldof, Germany.
Knorr U
Seitz R
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Article Info
Journal
Experimental brain research
Abbr.
Exp Brain Res
ISSN
0014-4819
DOI
10.1007/BF00233989
Published
1994-00-00
Pages
523-34
Language
English
Region
Germany
NLM ID
0043312
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00233989 View journal details
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