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PMID: 8078582 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

An early haematopoietic defect in mice lacking the transcription factor GATA-2.

Nature ·Vol. 371 ·No. 6494 ·1994-09-15 ·Pages 221-6

Tsai FY, Keller G, Kuo FC, Weiss M, Chen J, Rosenblatt M, Alt FW, Orkin SH

Abstract

Blood cell development relies on the expansion and maintenance of haematopoietic stem and progenitor cells in the embryo. By gene targeting in mouse embryonic stem cells, we demonstrate that the transcription factor GATA-2 plays a critical role in haematopoiesis, particularly of an adult type. We propose that GATA-2 regulates genes controlling growth factor responsiveness or the proliferative capacity of early haematopoietic cells.

Related Genes

GATA-2

MeSH Terms

Anemia/embryology Animals Base Sequence Bone Marrow/embryology Bone Marrow Cells Cells, Cultured DNA Primers DNA-Binding Proteins/genetics,metabolism Erythrocytes/cytology Female Fetal Death GATA2 Transcription Factor Gene Expression Regulation Genes, Lethal Hematopoiesis/genetics Male Mice Mice, Inbred C57BL Molecular Sequence Data Mutagenesis Restriction Mapping Spleen/cytology,embryology Stem Cells Transcription Factors/genetics,metabolism

Chemicals

DNA Primers DNA-Binding Proteins GATA2 Transcription Factor Gata2 protein, mouse Transcription Factors

Authors & Affiliations

8 authors, click to expand affiliations / ORCID

Tsai F Y

Division of Hematology-Oncology, Children's Hospital, Boston, Massachusetts.

Keller G

Kuo F C

Weiss M

Chen J

Rosenblatt M

Alt F W

Orkin S H

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/371221a0

Published

1994-09-15

Pages

221-6

Language

English

Region

England

NLM ID

0410462

Subset

External Links

PubMed source DOI: 10.1038/371221a0 View journal details

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An early haematopoietic defect in mice lacking the transcription factor GATA-2.

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