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PMID: 8083373 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Interleukin 1 is released by murine macrophages during apoptosis induced by Shigella flexneri.

The Journal of clinical investigation ·Vol. 94 ·No. 3 ·1994-09-00 ·Pages 1328-32

Zychlinsky A, Fitting C, Cavaillon JM, Sansonetti PJ

Abstract

Peritoneal macrophages undergoing apoptosis induced by Shigella flexneri infection release the inflammatory cytokine interleukin 1 (IL-1), but not IL-6 or tumor necrosis factor alpha (TNF alpha). Wild type shigella causes a very fast and significant release of IL-1 from prestimulated peritoneal macrophages, before the cell's integrity is compromised. Both IL-1 alpha and IL-1 beta are released, IL-1 beta in its mature processed form. IL-1 is released from presynthesized cytoplasmic pools. These results demonstrate that bacteria-induced apoptosis of macrophages may play an active role in vivo by releasing IL-1, which in turn mediates an early inflammatory response in epithelial tissues.

MeSH Terms
Animals Apoptosis Biological Assay Cells, Cultured Escherichia coli Interleukin-1/analysis,biosynthesis,metabolism Interleukin-6/analysis,biosynthesis,metabolism Lipopolysaccharides/toxicity Macrophages, Peritoneal/immunology,microbiology Male Mice Mice, Inbred C3H Shigella flexneri/pathogenicity
Chemicals
Interleukin-1 Interleukin-6 Lipopolysaccharides
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Zychlinsky A
Unité de Pathogénie Microbienne Moléculaire, Institut National de la Santé et de la Recherche Médicale U389, Institut Pasteur, Paris, France.
Fitting C
Cavaillon J M
Sansonetti P J
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Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/JCI117452
Published
1994-09-00
Pages
1328-32
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC295219
Subset
IM
External Links
PubMed source DOI: 10.1172/JCI117452 PMC Full Text View journal details
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