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PMID: 809000 Published · ppublish English Journal Article

Inhibition of ribosomal A site functions by sporangiomycin and micrococcin.

Antimicrobial agents and chemotherapy ·Vol. 8 ·No. 1 ·1975-07-00 ·Pages 1-4

Cundliffe E, Dixon PD

Abstract

Sporangiomycin and micrococcin inhibit the binding of aminoacyl-transfer ribonucleic acid into the ribosomal A site in intact bacterial protoplasts. They also prevent the assembly of [ribosome-elongation factor G-guanine nucleotide] complexes in vitro and compete with [(35)S]thiostrepton for ribosomal binding sites. We conclude that micrococcin and sporangiomycin block the ribosomal A site in the vicinity of the complex guanosine triphosphatase center and so resemble thiostrepton in their modes of action.

MeSH Terms
Anti-Bacterial Agents/pharmacology Bacillus megaterium/metabolism,ultrastructure Bacteriocins Escherichia coli/metabolism,ultrastructure Intercellular Signaling Peptides and Proteins Peptides/pharmacology RNA, Bacterial/metabolism RNA, Transfer/metabolism Ribosomes/drug effects Thiostrepton/metabolism
Chemicals
Anti-Bacterial Agents Bacteriocins Intercellular Signaling Peptides and Proteins Peptides RNA, Bacterial micrococcin sporangiomycin RNA, Transfer Thiostrepton
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Cundliffe E
Dixon P D
References (20)
20 references, click to expand
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.8.1.1
Published
1975-07-00
Pages
1-4
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC429249
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.8.1.1 PMC Full Text View journal details
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