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PMID: 8090766 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

A transposable element can drive the concerted evolution of tandemly repetitious DNA.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 91 ·No. 19 ·1994-09-13 ·Pages 9042-6

Thompson-Stewart D, Karpen GH, Spradling AC

Abstract

Recombination and conversion have been proposed to drive the concerted evolution of tandemly repeated DNA sequences. However, specific correction events within the repeated genes of multicellular organisms have not been observed directly, so their nature has remained speculative. We investigated whether the excision of transposable P elements from tandemly repeated sequences would induce unequal gene conversion. Genetically marked elements located in a subtelomeric repeat were mobilized, and the structure of the region was analyzed in progeny. We observed that the number of repeats was frequently altered. Decreases were more common than increases, and this bias probably resulted from intrinsic mechanisms governing P element-induced double-strand break repair. Our results suggest that transposable elements play an important role in the evolution of repetitious DNA.

MeSH Terms
Animals Biological Evolution DNA Transposable Elements Drosophila melanogaster/genetics Gene Conversion Repetitive Sequences, Nucleic Acid
Chemicals
DNA Transposable Elements
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Thompson-Stewart D
Howard Hughes Medical Institute Research Laboratories, Carnegic Institution of Washington, Baltimore, MD 21210.
Karpen G H
Spradling A C
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27 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.91.19.9042
Published
1994-09-13
Pages
9042-6
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC44743
Subset
IM
Grants
Howard Hughes Medical Institute · United States
NIGMS NIH HHS · GM27875 · United States
External Links
PubMed source DOI: 10.1073/pnas.91.19.9042 PMC Full Text View journal details
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