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PMID: 8092846 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Tetracycline resistance determinants in Mycobacterium and Streptomyces species.

Antimicrobial agents and chemotherapy ·Vol. 38 ·No. 6 ·1994-06-00 ·Pages 1408-12

Pang Y, Brown BA, Steingrube VA, Wallace RJ, Roberts MC

Abstract

Two of seven tetracycline-resistant (Tcr) Mycobacterium fortuitum group isolates and six Tcr clinical Streptomyces isolates carried gram-positive Tcr determinants (Tet K and Tet L) and Streptomyces resistance determinants (Otr A, Otr B, and Otr C). This represents the first documentation of the acquisition by mycobacteria of determinants coding for antibiotic resistance and suggests the potential for the spread of antibiotic resistance determinants within mycobacterial species.

MeSH Terms
Base Sequence Microbial Sensitivity Tests Molecular Sequence Data Mycobacterium/drug effects,genetics Polymerase Chain Reaction Streptomyces/drug effects,genetics Tetracycline Resistance/genetics
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Pang Y
Department of Pathobiology, University of Washington, Seattle 98195.
Brown B A
Steingrube V A
Wallace R J
Roberts M C
References (25)
25 references, click to expand
  1. Clinical usefulness of amikacin and doxycycline in the treatment of infection due to Mycobacterium fortuitum and Mycobacterium chelonei.
    Rev Infect Dis. 1981 Sep-Oct;3(5):1068-74 PMID: 7339806
  2. Spectrum of disease due to rapidly growing mycobacteria.
    Rev Infect Dis. 1983 Jul-Aug;5(4):657-79 PMID: 6353528
  3. Presence of aminoglycoside acetyltransferase and plasmids in Mycobacterium fortuitum. Lack of correlation with intrinsic aminoglycoside resistance.
    Am Rev Respir Dis. 1984 Apr;129(4):614-8 PMID: 6712002
  4. Treatment of nonpulmonary infections due to Mycobacterium fortuitum and Mycobacterium chelonei on the basis of in vitro susceptibilities.
    J Infect Dis. 1985 Sep;152(3):500-14 PMID: 3875667
  5. Rapidly growing mycobacteria: testing of susceptibility to 34 antimicrobial agents by broth microdilution.
    Antimicrob Agents Chemother. 1982 Aug;22(2):186-92 PMID: 6927280
  6. Conjugative transposons and the dissemination of antibiotic resistance in streptococci.
    Annu Rev Microbiol. 1986;40:635-59 PMID: 3022640
  7. Patterns and distribution of aminoglycoside-acetylating enzymes in rapidly growing mycobacteria.
    Am Rev Respir Dis. 1987 Aug;136(2):338-43 PMID: 3619192
  8. Human disease due to Mycobacterium smegmatis.
    J Infect Dis. 1988 Jul;158(1):52-9 PMID: 3392420
  9. Molecular cloning of resistance genes and architecture of a linked gene cluster involved in biosynthesis of oxytetracycline by Streptomyces rimosus.
    Mol Gen Genet. 1989 Jan;215(2):231-8 PMID: 2710100
  10. Genetic basis of tetracycline resistance in urogenital bacteria.
    Antimicrob Agents Chemother. 1990 Feb;34(2):261-4 PMID: 2327774
  11. Conjugative transfer of a shuttle plasmid from Escherichia coli to Mycobacterium smegmatis [corrected].
    FEMS Microbiol Lett. 1990 May;57(1-2):135-8 PMID: 2199300
  12. Clinical disease, drug susceptibility, and biochemical patterns of the unnamed third biovariant complex of Mycobacterium fortuitum.
    J Infect Dis. 1991 Mar;163(3):598-603 PMID: 1995732
  13. Plasmid analysis of Mycobacterium avium-intracellulare (MAI) isolated in the United Kingdom from patients with and without AIDS.
    J Med Microbiol. 1991 Apr;34(4):225-31 PMID: 2020017
  14. Transformation of Mycobacterium aurum and Mycobacterium smegmatis with the broad host-range gram-negative cosmid vector pJRD215.
    Mol Microbiol. 1991 Jun;5(6):1561-6 PMID: 1787803
  15. Characterization of an oxytetracycline-resistance gene, otrA, of Streptomyces rimosus.
    Mol Microbiol. 1991 Dec;5(12):2923-33 PMID: 1809836
  16. An outbreak of multidrug-resistant tuberculosis among hospitalized patients with the acquired immunodeficiency syndrome.
    N Engl J Med. 1992 Jun 4;326(23):1514-21 PMID: 1304721
  17. Skin, soft tissue, and bone infections due to Mycobacterium chelonae chelonae: importance of prior corticosteroid therapy, frequency of disseminated infections, and resistance to oral antimicrobials other than clarithromycin.
    J Infect Dis. 1992 Aug;166(2):405-12 PMID: 1386098
  18. The catalase-peroxidase gene and isoniazid resistance of Mycobacterium tuberculosis.
    Nature. 1992 Aug 13;358(6387):591-3 PMID: 1501713
  19. The unstable tetracycline resistance gene of Streptomyces lividans 1326 encodes a putative protein with similarities to translational elongation factors and Tet(M) and Tet(O) proteins.
    Antimicrob Agents Chemother. 1992 May;36(5):1119-24 PMID: 1510403
  20. Bacterial resistance to tetracycline: mechanisms, transfer, and clinical significance.
    Clin Microbiol Rev. 1992 Oct;5(4):387-99 PMID: 1423217
  21. Isolation and characterization of isoniazid-resistant mutants of Mycobacterium smegmatis and M. aurum.
    Res Microbiol. 1992 Sep;143(7):721-30 PMID: 1488556
  22. Characterization of antibiotic-resistant Corynebacterium striatum strains.
    J Antimicrob Chemother. 1992 Oct;30(4):463-74 PMID: 1490919
  23. Detection of rifampicin-resistance mutations in Mycobacterium tuberculosis.
    Lancet. 1993 Mar 13;341(8846):647-50 PMID: 8095569
  24. Tuberculosis: the return of an old enemy.
    Crit Rev Microbiol. 1993;19(1):1-16 PMID: 8481210
  25. Detection of Tet M and Tet O tetracycline resistance genes by polymerase chain reaction.
    Mol Cell Probes. 1993 Oct;7(5):387-93 PMID: 8264673
Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.38.6.1408
Published
1994-06-00
Pages
1408-12
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC188220
Subset
IM
Grants
NIAID NIH HHS · AI24136 · United States
Databases
GENBANK
S74032
External Links
PubMed source DOI: 10.1128/AAC.38.6.1408 PMC Full Text View journal details
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