Preparation of Rocky Mountain spotted fever vaccine suitable for human immunization.

Journal of clinical microbiology ·Vol. 1 ·No. 6 ·1975-06-00 ·Pages 500-3

Kenyon RH, Pedersen CE

Abstract

Rocky Mountain spotted fever vaccine was produced from rickettsiae grown in chicken embryo cells in roller bottle cultures. The rickettsiae were concentrated and purified by passage through a sucrose gradient and inactivated with formalin. This vaccine satisfactorily passed preinactivation and final container testing and is believed to be superior to the presently available yolk sac vaccine.

MeSH Terms

Animals Drug Evaluation, Preclinical Formaldehyde/pharmacology Guinea Pigs Humans Immunization Immunochemistry Rickettsia rickettsii/drug effects,immunology Rickettsial Vaccines Rocky Mountain Spotted Fever/prevention & control Vaccines Vaccines, Attenuated

Chemicals

Rickettsial Vaccines Vaccines Vaccines, Attenuated Formaldehyde

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Kenyon R H

Pedersen C E

References (10)

10 references, click to expand

Immunization against scrub typhus. II. Preparation of lyophilized living vaccine.
Am J Hyg. 1951 May;53(3):326-31 PMID: 14829444
Method for counting Rickettsiae and Chlamydiae in purified suspensions.
J Bacteriol. 1968 Jan;95(1):259-61 PMID: 4866101
Rocky Mountain spotted fever acquired in a laboratory.
N Engl J Med. 1967 Oct 19;277(16):842-7 PMID: 6046683
Rocky Mountain spotted fever. Laboratory infection in a vaccinated individual.
JAMA. 1970 Mar 23;211(12):2012-4 PMID: 4984704
Rickettsial diseases in the United States.
Med Clin North Am. 1959 Sep;43:1507-35 PMID: 13845913
Public Health Weekly Reports for OCTOBER 9, 1925.
Public Health Rep. 1925 Oct 9;40(41):2159-2208 PMID: 19315003
Hemadsorption (adsorption-hemagglutination) test for viral agents in tissue culture with special reference to influenza.
Proc Soc Exp Biol Med. 1958 Apr;97(4):802-9 PMID: 13554486
Protein measurement with the Folin phenol reagent.
J Biol Chem. 1951 Nov;193(1):265-75 PMID: 14907713
Rocky Mountain spotted fever: a comparative study of the active immunity induced by inactivated and viable pathogenic Rickettsia rickettsii.
J Infect Dis. 1973 Sep;128(3):340-4 PMID: 4199563
Preparation of vaccines for Rocky Mountain spotted fever from rickettsiae propagated in cell culture.
J Infect Dis. 1972 Feb;125(2):146-52 PMID: 4621411

Article Info

Journal

Journal of clinical microbiology

Abbr.

J Clin Microbiol

ISSN

0095-1137

DOI

10.1128/jcm.1.6.500-503.1975

Published

1975-06-00

Pages

500-3

Language

English

Region

United States

NLM ID

7505564

PMCID

PMC275168

Subset

External Links

PubMed source DOI: 10.1128/jcm.1.6.500-503.1975 PMC Full Text View journal details

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Preparation of Rocky Mountain spotted fever vaccine suitable for human immunization.

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