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PMID: 8096813 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Separable regulatory elements mediate the establishment and maintenance of cell states by the Drosophila segment-polarity gene gooseberry.

The EMBO journal ·Vol. 12 ·No. 4 ·1993-04-00 ·Pages 1427-36

Li X, Gutjahr T, Noll M

Abstract

During Drosophila embryogenesis, position along the anteroposterior axis is specified within each segment by the products of the segment-polarity genes which include wingless (wg) and gooseberry (gsb). The striped expression of these genes in each segment is initially established by the pair-rule gene products during late blastoderm. This pattern is subsequently maintained after germ band extension by interaction among the segment-polarity genes themselves. Here we show that the maintenance of gsb, a PHox gene encoding a paired-domain and a homeodomain, is controlled by the wg signal, the homolog of the murine Wnt-1 protein. A control element responsible for wg-dependent maintenance of gsb expression, gsb-late element, is separable from an element required for the initial activation of gsb by pair-rule transcription factors, gsb-early element. The significance of such a regulatory strategy is discussed with respect to the establishment and maintenance of cell states within each segment by segment-polarity genes.

Related Genes
gsb wg
MeSH Terms
Animals Base Sequence DNA-Binding Proteins/genetics Drosophila melanogaster/embryology,genetics Gene Expression Regulation Genes, Homeobox Molecular Sequence Data Morphogenesis Oligodeoxyribonucleotides/chemistry RNA, Messenger/genetics Regulatory Sequences, Nucleic Acid Transcription Factors/physiology
Chemicals
DNA-Binding Proteins Oligodeoxyribonucleotides RNA, Messenger Transcription Factors
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Li X
Institute for Molecular Biology II, University of Zürich, Switzerland.
Gutjahr T
Noll M
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34 references, click to expand
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Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
0261-4189
Published
1993-04-00
Pages
1427-36
Language
English
Region
England
NLM ID
8208664
PMCID
PMC413354
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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