Comparative study of membrane and intracytoplasmic immunoglobulin classes in human lymphoid cells.

Annals of the New York Academy of Sciences ·Vol. 254 ·1975-06-30 ·Pages 243-53

Ferrarini M, Bargellesi A, Corte G, Viale G, Pernis B

Abstract

Immunofluorescent and "in vitro" biosynthetic techniques have been used to study the connections between the maturation process of human lymphocytes that leads to the appearance of actively secreting cells and a possible switchover from IgD to IgM production, both in homogeneous CLL cell populations and in heterogeneous cell suspensions from tonsils. The results obtained are compatible with the hypothesis that the switchover from IgD to IgM productions can be a clonal maturation phenomenon.

MeSH Terms

Antibody-Producing Cells Binding Sites, Antibody Bone Marrow/immunology Bone Marrow Cells Cell Membrane/immunology Cytoplasm/immunology Fluorescent Antibody Technique Humans Immunoglobulin A Immunoglobulin D/analysis Immunoglobulin Fab Fragments Immunoglobulin G Immunoglobulin M/analysis Immunoglobulin kappa-Chains Immunoglobulin lambda-Chains Leucine/metabolism Leukemia, Lymphoid/blood Lymphocytes/immunology Molecular Weight Palatine Tonsil/immunology Threonine/metabolism Valine/metabolism

Chemicals

Immunoglobulin A Immunoglobulin D Immunoglobulin Fab Fragments Immunoglobulin G Immunoglobulin M Immunoglobulin kappa-Chains Immunoglobulin lambda-Chains Threonine Leucine Valine

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Ferrarini M

Bargellesi A

Corte G

Viale G

Pernis B

Article Info

Journal

Annals of the New York Academy of Sciences

Abbr.

Ann N Y Acad Sci

ISSN

0077-8923

DOI

10.1111/j.1749-6632.1975.tb29174.x

Published

1975-06-30

Pages

243-53

Language

English

Region

United States

NLM ID

7506858

Subset

External Links

PubMed source DOI: 10.1111/j.1749-6632.1975.tb29174.x View journal details

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Comparative study of membrane and intracytoplasmic immunoglobulin classes in human lymphoid cells.

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