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PMID: 8100997 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Comment

Interleukin 12 in host defense against microbial pathogens.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 90 ·No. 13 ·1993-07-01 ·Pages 5879-80

Locksley RM

Abstract

暂无摘要

MeSH Terms

Animals Humans Immunity, Innate Infections/immunology Interferon-gamma/biosynthesis Interleukin-12 Interleukins/physiology Mice Mice, SCID T-Lymphocytes/immunology

Chemicals

Interleukins Interleukin-12 Interferon-gamma

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Locksley R M

Department of Medicine, University of California San Francisco 94143-0654.

References (15)

15 references, click to expand

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IL-4 directs the development of Th2-like helper effectors.
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Cytokine-induced synthesis of nitrogen oxides in macrophages: a protective host response to Leishmania and other intracellular pathogens.
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Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes.
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Differential regulation of T helper phenotype development by interleukins 4 and 10 in an alpha beta T-cell-receptor transgenic system.
Proc Natl Acad Sci U S A. 1992 Jul 1;89(13):6065-9 PMID: 1385868
The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice.
J Exp Med. 1992 Oct 1;176(4):1091-8 PMID: 1328464
Induction of TH1 and TH2 responses: a key role for the 'natural' immune response?
Immunol Today. 1992 Oct;13(10):379-81 PMID: 1418371
Interferon gamma inhibits interleukin 10 production by monocytes.
J Exp Med. 1993 Feb 1;177(2):523-7 PMID: 8426121
Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist.
Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3725-9 PMID: 8097322
IL-12: initiation cytokine for cell-mediated immunity.
Science. 1993 Apr 23;260(5107):496-7 PMID: 8097337
Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages.
Science. 1993 Apr 23;260(5107):547-9 PMID: 8097338
Recombinant interleukin 12 cures mice infected with Leishmania major.
J Exp Med. 1993 May 1;177(5):1505-9 PMID: 8097524
Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts.
Proc Natl Acad Sci U S A. 1993 Jul 1;90(13):6115-9 PMID: 8100999

Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.90.13.5879

Published

1993-07-01

Pages

5879-80

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC46829

Subset

Grants

NIAID NIH HHS · AI130663 · United States

NIAID NIH HHS · AI26918 · United States

Corrections

CommentOn

PMID: 8100999

External Links

PubMed source DOI: 10.1073/pnas.90.13.5879 PMC Full Text View journal details

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