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PMID: 812484 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Transport defects as the physiological basis for eye color mutants of Drosophila melanogaster.

Biochemical genetics ·Vol. 13 ·No. 9-10 ·1975-10-00 ·Pages 603-13

Sullivan DT, Sullivan MC

Abstract

Kynurenine-H3 transport and conversion to 3-hydroxykynurenine were studied in organ culture using the Malpighian tubules and developing eyes from wild type and the eye color mutants w, st, ltd, ca, and cn of Drosophila melanogaster. Malpighian tubules from wild type have the ability to concentrate kynurenine and convert it to 3-hydroxykynurenine. The tubules from w, st, ltd, and ca are deficient in the ability to transport kynurenine, as are the eyes of the mutants w, st, and ltd. This defect in kynurenine transport provides a physiological explanation for the phenotypic properties of the mutants. The relationship of these measurements to previous observations on these eye color mutants is discussed and the transport defect hypothesis is consistently supported. We have concluded that several of the eye color mutants in Drosophila are transport mutants.

MeSH Terms
Animals Drosophila melanogaster/metabolism Eye Color Genotype Inulin/metabolism Kynurenine/analogs & derivatives,metabolism Larva/metabolism Malpighian Tubules/metabolism Mutation
Chemicals
Kynurenine Inulin
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Sullivan D T
Sullivan M C
References (11)
11 references, click to expand
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Article Info
Journal
Biochemical genetics
Abbr.
Biochem Genet
ISSN
0006-2928
DOI
10.1007/BF00484918
Published
1975-10-00
Pages
603-13
Language
English
Region
United States
NLM ID
0126611
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00484918 View journal details
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