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PMID: 813009 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Transformation of human osteosarcoma cells by a chemical carcinogen.

Journal of the National Cancer Institute ·Vol. 55 ·No. 6 ·1975-12-00 ·Pages 1291-4

Rhim JS, Kim CM, Arnstein P, Huebner RJ, Weisburger EK, Nelson Ress WA

Abstract

A human osteosarcoma clonal cell line (TE-85, clone F-5) was treated in vitro with various levels of 7,12-dimethylbenz[a]anthracene or dimethyl sulfoxide (control). Cells treated only with the carcinogen underwent morphologic alteration in vitro, and one of these altered cell lines produced tumors subcutaneously and intracerebrally when injected into NIH nude mice.

MeSH Terms

9,10-Dimethyl-1,2-benzanthracene/pharmacology Animals Benz(a)Anthracenes/pharmacology Cell Line Cell Transformation, Neoplastic Clone Cells Dimethyl Sulfoxide/pharmacology Mice Mice, Nude Neoplasms, Experimental/etiology,pathology Osteosarcoma/pathology

Chemicals

Benz(a)Anthracenes 9,10-Dimethyl-1,2-benzanthracene Dimethyl Sulfoxide

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Rhim J S

Kim C M

Arnstein P

Huebner R J

Weisburger E K

Nelson Ress W A

Article Info

Journal

Journal of the National Cancer Institute

Abbr.

J Natl Cancer Inst

ISSN

0027-8874

DOI

10.1093/jnci/55.6.1291

Published

1975-12-00

Pages

1291-4

Language

English

Region

United States

NLM ID

7503089

Subset

External Links

PubMed source DOI: 10.1093/jnci/55.6.1291 View journal details

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Transformation of human osteosarcoma cells by a chemical carcinogen.

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