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PMID: 8137121 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

On the mechanism of action of quinolone drugs.

Trends in microbiology ·Vol. 1 ·No. 6 ·1993-09-00 ·Pages 232-5

Palumbo M, Gatto B, Zagotto G, Palù G

Abstract

Antibacterial quinolones are thought to inhibit DNA gyrase by trapping the enzyme as a complex with the DNA substrate. The precise molecular details of drug-DNA and drug-enzyme interactions remain controversial. Here, a model is proposed that accounts for the influence of magnesium ions on quinolone-DNA binding.

Related Genes
gyrA gyrB
MeSH Terms
4-Quinolones Anti-Infective Agents/metabolism Bacteria/enzymology DNA Topoisomerases, Type II/genetics,metabolism Drug Resistance, Microbial/genetics Magnesium/physiology Models, Biological
Chemicals
4-Quinolones Anti-Infective Agents DNA Topoisomerases, Type II Magnesium
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Palumbo M
Dept of Pharmaceutical Sciences, University of Padova, Italy.
Gatto B
Zagotto G
Palù G
Article Info
Journal
Trends in microbiology
Abbr.
Trends Microbiol
ISSN
0966-842X
DOI
10.1016/0966-842x(93)90138-h
Published
1993-09-00
Pages
232-5
Language
English
Region
England
NLM ID
9310916
Subset
IM
External Links
PubMed source DOI: 10.1016/0966-842x(93)90138-h View journal details
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