Cell-mediated immunity in patients with cystic fibrosis.

British medical journal ·Vol. 1 ·No. 6002 ·1976-01-17 ·Pages 120-2

Gibbons A, Allan JD, Holzel A, McFarlane H

Abstract

Leucocytes from 26 patients with cystic fibrosis (CF) and 18 healthy controls were investigated by migration inhibition induced by a variety of antigens. In patients with CF cell-mediated immunity was found to human lung and pancreatic tissue extracts as well as to Aspergillus fumigatus, Pseudomonas aeruginosa, and food antigens but not to brain, heart, or kidney. Those patients with the severest form of the disease had the greatest impairment of cell-mediated immunity, but this impairment could be reversed by steroid treatment. Cell-mediated cytotoxicity may also be concerned in the pathogenesis of CF.

MeSH Terms

Adolescent Adult Animals Antigens Antigens, Fungal Aspergillus fumigatus/immunology Cell Migration Inhibition Child Child, Preschool Cystic Fibrosis/drug therapy,immunology Female Guinea Pigs Humans Immunity, Cellular Infant Leukocytes/immunology Lung/immunology Macrophages/immunology Male Pancreas/immunology Prednisolone/therapeutic use Pseudomonas aeruginosa/immunology

Chemicals

Antigens Antigens, Fungal Prednisolone

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Gibbons A

Allan J D

Holzel A

McFarlane H

References (4)

4 references, click to expand

The clinical significance of circulating pancreatic antibodies.
Ann Intern Med. 1960 Sep;53:548-55 PMID: 13727030
Human lymphocyte migration as a parameter of hypersensitivity.
Acta Med Scand. 1967 Feb;181(2):247-56 PMID: 6017822
Precipitating antibodies to aspergillus fumigatus in cystic fibrosis.
Lancet. 1967 Mar 11;1(7489):538-9 PMID: 4163904
Cystic fibrosis--immunological reactions to A. fumigatus and common allergens.
Clin Allergy. 1975 Mar;5(1):1-12 PMID: 802880

Article Info

Journal

British medical journal

Abbr.

Br Med J

ISSN

0007-1447

DOI

10.1136/bmj.1.6002.120

Published

1976-01-17

Pages

120-2

Language

English

Region

England

NLM ID

0372673

PMCID

PMC1638654

Subset

External Links

PubMed source DOI: 10.1136/bmj.1.6002.120 PMC Full Text

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Cell-mediated immunity in patients with cystic fibrosis.

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