Home LiteratureArticle Details

PMID: 8142619 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

TAL1, TAL2 and LYL1: a family of basic helix-loop-helix proteins implicated in T cell acute leukaemia.

Seminars in cancer biology ·Vol. 4 ·No. 6 ·1993-12-00 ·Pages 341-7

Baer R

Abstract

TAL1 gene rearrangement is the most common genetic defect associated with T cell acute lymphoblastic leukaemia (T-ALL). Tumour-specific rearrangements of TAL1 arise as a result of either chromosome translocation or local DNA recombination. TAL1 gene products possess the basic helix-loop-helix (bHLH) motif, a DNA-binding domain common to several known transcription factors. The bHLH domain of TAL1 is especially homologous to those encoded by TAL2 and LYL1, distinct genes that were also identified on the basis of chromosomal rearrangement in T-ALL. Thus, TAL1, TAL2 and LYL1 constitute a unique family of bHLH proteins, each of which is a potential mediator of T cell leukaemogenesis.

MeSH Terms

Amino Acid Sequence Animals Base Sequence Basic Helix-Loop-Helix Transcription Factors Chromosomes, Human/ultrastructure Consensus Sequence DNA-Binding Proteins/genetics,physiology Gene Expression Regulation, Leukemic Gene Rearrangement, T-Lymphocyte Genes, myc Helix-Loop-Helix Motifs/physiology Humans Leukemia-Lymphoma, Adult T-Cell/genetics Mice Molecular Sequence Data Multigene Family Neoplasm Proteins/genetics,physiology Proto-Oncogene Proteins Recombination, Genetic Sequence Alignment Sequence Homology, Amino Acid T-Cell Acute Lymphocytic Leukemia Protein 1 T-Lymphocytes/metabolism,pathology Transcription Factors Translocation, Genetic

Chemicals

Basic Helix-Loop-Helix Transcription Factors DNA-Binding Proteins LYL1 protein, human Lyl1 protein, mouse Neoplasm Proteins Proto-Oncogene Proteins T-Cell Acute Lymphocytic Leukemia Protein 1 TAL2 protein, human Tal1 protein, mouse Tal2 protein, mouse Transcription Factors TAL1 protein, human

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Baer R

Department of Microbiology, University of Texas, Southwestern Medical Center, Dallas 75235.

Article Info

Journal

Seminars in cancer biology

Abbr.

Semin Cancer Biol

ISSN

1044-579X

Published

1993-12-00

Pages

341-7

Language

English

Region

England

NLM ID

9010218

Subset

Grants

NCI NIH HHS · CA44016 · United States

NCI NIH HHS · CA46593 · United States

External Links

PubMed source View journal details

Analysis Services

TAL1, TAL2 and LYL1: a family of basic helix-loop-helix proteins implicated in T cell acute leukaemia.

Contact

WeChat Official Account