Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor.

Science (New York, N.Y.) ·Vol. 264 ·No. 5161 ·1994-05-13 ·Pages 965-8

Grabstein KH, Eisenman J, Shanebeck K, Rauch C, Srinivasan S, Fung V, Beers C, Richardson J, Schoenborn MA, Ahdieh M

Abstract

A cytokine was identified that stimulated the proliferation of T lymphocytes, and a complementary DNA clone encoding this new T cell growth factor was isolated. The cytokine, designated interleukin-15 (IL-15), is produced by a wide variety of cells and tissues and shares many biological properties with IL-2. Monoclonal antibodies to the beta chain of the IL-2 receptor inhibited the biological activity of IL-15, and IL-15 competed for binding with IL-2, indicating that IL-15 uses components of the IL-2 receptor.

MeSH Terms

Amino Acid Sequence Animals Cells, Cultured Cloning, Molecular Haplorhini Humans Interleukin-15 Interleukin-2/immunology,metabolism,pharmacology Interleukins/chemistry,genetics,metabolism,pharmacology Killer Cells, Lymphokine-Activated/immunology Leukocytes, Mononuclear/immunology,metabolism Lymphocyte Activation Lymphocyte Culture Test, Mixed Molecular Sequence Data Protein Structure, Secondary Receptors, Interleukin-2/immunology,metabolism T-Lymphocytes/immunology T-Lymphocytes, Cytotoxic/immunology

Chemicals

Interleukin-15 Interleukin-2 Interleukins Receptors, Interleukin-2

Authors & Affiliations

10 authors, click to expand affiliations / ORCID

Grabstein K H

Immunex Research and Development Corporation, Seattle, WA 98101.

Eisenman J

Shanebeck K

Rauch C

Srinivasan S

Fung V

Beers C

Richardson J

Schoenborn M A

Ahdieh M

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.8178155

Published

1994-05-13

Pages

965-8

Language

English

Region

United States

NLM ID

0404511

Subset

Databases

GENBANK

U03099, U14407

External Links

PubMed source DOI: 10.1126/science.8178155 View journal details

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Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor.

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