Selective activation of classical and alternative pathways of human complement by "promptly serum-sensitive" and "delayed serum-sensitive" strains of Serratia marcescens.

Infection and immunity ·Vol. 13 ·No. 5 ·1976-05-00 ·Pages 1343-6

Traub WH, Kleber I

Abstract

Chelation of fresh human serum with 0.01 M MgCl2 (Mg) plus 0.01 M ethylene glycol tetraacetic acid failed to abrogate the bactericidal activity against "delayed serum-sensitive" strains of Serratia marcescens, whereas previously "promptly serum-sensitive" strains of S. marcescens and control strain Escherichia coli C were killed after an extended period of incubation. The addition of 0.01 M ethylenediametetracetate to fresh human serum neutralized bactericidal activity against S. marcescens of either serum sensitivity category.

MeSH Terms

Blood Bactericidal Activity Cations, Divalent Complement System Proteins/metabolism Edetic Acid/pharmacology Egtazic Acid/pharmacology Humans In Vitro Techniques Magnesium/pharmacology Serratia marcescens/immunology Time Factors

Chemicals

Cations, Divalent Egtazic Acid Complement System Proteins Edetic Acid Magnesium

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Traub W H

Kleber I

References (12)

12 references, click to expand

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Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.13.5.1343-1346.1976

Published

1976-05-00

Pages

1343-6

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC420762

Subset

External Links

PubMed source DOI: 10.1128/iai.13.5.1343-1346.1976 PMC Full Text View journal details

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Selective activation of classical and alternative pathways of human complement by "promptly serum-sensitive" and "delayed serum-sensitive" strains of Serratia marcescens.

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