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PMID: 8184 Published · ppublish English Clinical Trial Comparative Study Controlled Clinical Trial Journal Article

Comparison of atenolol and propranolol during insulin-induced hypoglycaemia.

British medical journal ·Vol. 2 ·No. 6030 ·1976-07-31 ·Pages 272-3

Deacon SP, Barnett D

Abstract

The effects of atenolol, a new beta1-blocking drug, on pulse rate, sweating, and blood glucose levels during insulin-induced hypoglycaemia were studied in a double-blind crossover trial in eight normal subjects using placebo and propranolol as reference agents. The intensity of induced hypoglycaemia was identical for atenolol, propranolol, and placebo. Propranolol prolonged hypoglycaemia, but atenolol did not. Atenolol may therefore be safe for use in patients receiving insulin.

MeSH Terms
Adrenergic beta-Antagonists/pharmacology Adult Atenolol/pharmacology Blood Glucose Clinical Trials as Topic Depression, Chemical Heart Rate/drug effects Humans Hypoglycemia/chemically induced Insulin/pharmacology Male Placebos Propanolamines/pharmacology Propranolol/pharmacology Pulse/drug effects Sweating/drug effects Time Factors
Chemicals
Adrenergic beta-Antagonists Blood Glucose Insulin Placebos Propanolamines Atenolol Propranolol
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Deacon S P
Barnett D
References (5)
5 references, click to expand
  1. Hypoglycemia: a potent stimulus to secretion of growth hormone.
    Science. 1963 May 31;140(3570):987-8 PMID: 13975313
  2. THE ADRENOCORTICAL RESPONSE TO INSULIN-INDUCED HYPOGLYCAEMIA.
    J Endocrinol. 1963 Nov;27:183-92 PMID: 14079508
  3. Effects of propranolol on the hormonal and metabolic responses to insulin-induced hypoglycaemia.
    Lancet. 1966 Dec 24;2(7478):1386-8 PMID: 4163545
  4. Propranolol-induced hypoglycaemia and myocardial infarction.
    Br Med J. 1972 Jun 3;2(5813):592 PMID: 5032795
  5. Once-daily dosing with Atenolol in patients with mild or moderate hypertension.
    Br Med J. 1976 Apr 24;1(6016):990-1 PMID: 773494
Article Info
Journal
British medical journal
Abbr.
Br Med J
ISSN
0007-1447
DOI
10.1136/bmj.2.6030.272
Published
1976-07-31
Pages
272-3
Language
English
Region
England
NLM ID
0372673
PMCID
PMC1687873
Subset
IM
External Links
PubMed source DOI: 10.1136/bmj.2.6030.272 PMC Full Text
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