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PMID: 818639 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

A new immunoglobulin variant: gamma3 heavy chain disease protein CHI.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 73 ·No. 5 ·1976-05-00 ·Pages 1552-5

Frangione B

Abstract

Protein CHI is a defective human gamma3 heavy chain immunoglobulin with a deletion encompassing a portion of the variable and constant regions. Joining of the two pieces takes place at the beginning of an extra fragment (Fh) in the constant region where repetitive sequences are found, apparently as the result of gene duplications and/or unequal crossover between gamma genes. It is postulated that a 45 nucleotide fragment is the repetitive unit coding for the extra fragment.

MeSH Terms
Amino Acid Sequence Amino Acids/analysis Chromosome Deletion Crossing Over, Genetic Genes Heavy Chain Disease Humans Immunoglobulin Heavy Chains/biosynthesis Immunoglobulin gamma-Chains/analysis,biosynthesis
Chemicals
Amino Acids Immunoglobulin Heavy Chains Immunoglobulin gamma-Chains
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Frangione B
References (25)
25 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.73.5.1552
Published
1976-05-00
Pages
1552-5
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC430335
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.73.5.1552 PMC Full Text View journal details
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