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PMID: 8188270 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Molecular cloning and chromosomal localization of the human alpha 7-nicotinic receptor subunit gene (CHRNA7).

Genomics ·Vol. 19 ·No. 2 ·1994-01-15 ·Pages 379-81

Chini B, Raimond E, Elgoyhen AB, Moralli D, Balzaretti M, Heinemann S

Abstract

We have isolated cDNA and genomic clones coding for the human alpha 7 neuronal nicotinic receptor subunit, the major component of brain nicotinic receptors that are blocked by alpha-bungarotoxin. The human alpha 7 neuronal nicotinic cDNA encodes a mature protein of 479 amino acids that is highly homologous to the rat alpha 7 neuronal nicotinic subunit (90%). We have mapped the human alpha 7-nicotinic receptor subunit gene to chromosome 15, band q14, a region frequently rearranged in patients carrying a bisatellite 15 chromosome, large inv dup (15), whose clinical features include mental retardation and seizures.

Related Genes

CHRNA7

MeSH Terms

Amino Acid Sequence Animals Base Sequence Chromosome Aberrations/genetics Chromosome Disorders Chromosome Inversion Chromosome Mapping Chromosomes, Human, Pair 15 Cloning, Molecular DNA, Complementary/genetics Epilepsy/genetics Genes Humans Intellectual Disability/genetics Mice Molecular Sequence Data Rats Receptors, Nicotinic/genetics Sequence Homology, Nucleic Acid Species Specificity Syndrome alpha7 Nicotinic Acetylcholine Receptor

Chemicals

Chrna7 protein, human Chrna7 protein, mouse Chrna7 protein, rat DNA, Complementary Receptors, Nicotinic alpha7 Nicotinic Acetylcholine Receptor

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Chini B

Molecular Neurobiology Laboratory, Salk Institute, La Jolla, California 92037.

Raimond E

Elgoyhen A B

Moralli D

Balzaretti M

Heinemann S

Article Info

Journal

Genomics

Abbr.

Genomics

ISSN

0888-7543

DOI

10.1006/geno.1994.1075

Published

1994-01-15

Pages

379-81

Language

English

Region

United States

NLM ID

8800135

Subset

Grants

NINDS NIH HHS · NS11549 · United States

Databases

GENBANK

Z23141

External Links

PubMed source DOI: 10.1006/geno.1994.1075 View journal details

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Molecular cloning and chromosomal localization of the human alpha 7-nicotinic receptor subunit gene (CHRNA7).

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