Frapper fort ou frapper doucement: a gram-negative dilemma.

Lancet (London, England) ·Vol. 2 ·No. 8101 ·1978-12-02 ·Pages 1193-4

Hopkin DA

Abstract

Although antibiotics can clear gram-negative organisms from the circulation in a short time, large numbers of patients continue to die from gram-negative shock. Research carried out more than 25 years ago indicates that the replacement of the current antibiotic approach of "frappez fort et vite" by one of "frappez doucement" may reduce the incidence and mortality of gram-negative shock.

MeSH Terms

Animals Antitoxins/administration & dosage Bacterial Toxins/adverse effects Chloramphenicol/administration & dosage Chlorpromazine/administration & dosage Cortisone/administration & dosage Endotoxins/adverse effects Guinea Pigs Humans Injections, Intramuscular Injections, Subcutaneous Salmonella typhi/drug effects Shock, Septic/etiology,mortality,prevention & control Typhoid Fever/complications,microbiology

Chemicals

Antitoxins Bacterial Toxins Endotoxins Chloramphenicol Chlorpromazine Cortisone

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Hopkin D A

Article Info

Journal

Lancet (London, England)

Abbr.

Lancet

ISSN

0140-6736

Published

1978-12-02

Pages

1193-4

Language

English

Region

England

NLM ID

2985213R

Subset

External Links

PubMed source View journal details

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Frapper fort ou frapper doucement: a gram-negative dilemma.

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