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PMID: 8215583 Published · ppublish English Journal Article

In situ hybridization analysis of cytokine, proto-oncogene and tumour suppressor gene expression in psoriasis.

Archives of dermatological research ·Vol. 285 ·No. 6 ·1993-00-00 ·Pages 334-40

Schmid P, Cox D, McMaster GK, Itin P

Abstract

The purpose of this study was to investigate and to compare, by in situ hybridization, gene expression of IL-1 beta, IL-8, TGF-beta 1, TGF-beta 2, TGF-beta 3, TGF-alpha, p53 and c-myc in lesions and in non-involved skin of patients with psoriasis. All lesional skin biopsies showed overexpression of IL-1 beta, IL-8 TGF-alpha mRNAs. IL-1 beta hybridization signals were strong in a small number of cells localized predominantly in the dermal papillae and in the suprapapillary epidermis. Overexpression of TGF-alpha was observed in all suprabasal keratinocytes, whereas strongly elevated IL-8 mRNA expression was found to be restricted to clusters of suprabasal keratinocytes. TGF-beta 3, p53 and c-myc transcripts were clearly detected in the epidermis of all biopsies, although expression levels were comparable in lesional and non-lesional skin.

Related Genes
IL-1 beta IL-8 TGF-alpha TGF-beta 1 TGF-beta 2 TGF-beta 3 c-myc p53
MeSH Terms
Cytokines/genetics Gene Expression Genes, Tumor Suppressor Genes, myc Genes, p53 Humans In Situ Hybridization Interleukin-1/genetics Interleukin-8/genetics Proto-Oncogene Mas Proto-Oncogenes Psoriasis/genetics,immunology Transforming Growth Factor alpha/genetics Transforming Growth Factor beta/genetics
Chemicals
Cytokines Interleukin-1 Interleukin-8 MAS1 protein, human Proto-Oncogene Mas Transforming Growth Factor alpha Transforming Growth Factor beta
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Schmid P
CIBA-GEIGY Ltd., Pharma Division, Basel, Switzerland.
Cox D
McMaster G K
Itin P
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25 references, click to expand
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Article Info
Journal
Archives of dermatological research
Abbr.
Arch Dermatol Res
ISSN
0340-3696
DOI
10.1007/BF00371833
Published
1993-00-00
Pages
334-40
Language
English
Region
Germany
NLM ID
8000462
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00371833 View journal details
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