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PMID: 822114 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Protection against group B meningococcal disease. I. Comparison of group-specific and type-specific protection in the chick embryo model.

The Journal of experimental medicine ·Vol. 144 ·No. 2 ·1976-08-01 ·Pages 319-29

Frasch CE, Parkes L, McNelis RM, Gotschlich EC

Abstract

Protection against group B meningococcal infection was examined using the chick embryo. 12-day-old embryos were challenged intravenously with various meningococcal strains. The chick embryo has an active reticuloendothelial system but lacks functional complement. In this model we found that protection against group B infection was primarily group specific. The group B polysaccharide antibody is an effective opsonin, but is a very poor bactericidal antibody. In contrast, the serotype antibody was bactericidal but only slightly protective in the chick embryo where protection is primarily phagocytic in nature. The group-specific and type-specific antibodies are strongly synergistic. Minute amounts of group B polysaccharide antibody caused a very significant increase in the protective effects of the serotype antibody.

MeSH Terms

Animals Antibodies, Bacterial Antibody Specificity Chick Embryo Disease Models, Animal Immunization Meningococcal Infections/immunology,prevention & control Neisseria meningitidis/immunology Polysaccharides, Bacterial/immunology Serotyping

Chemicals

Antibodies, Bacterial Polysaccharides, Bacterial

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Frasch C E

Parkes L

McNelis R M

Gotschlich E C

References (23)

23 references, click to expand

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Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.144.2.319

Published

1976-08-01

Pages

319-29

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2190389

Subset

External Links

PubMed source DOI: 10.1084/jem.144.2.319 PMC Full Text View journal details

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Protection against group B meningococcal disease. I. Comparison of group-specific and type-specific protection in the chick embryo model.

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