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PMID: 8226698 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Negative autoregulation by the Escherichia coli SoxS protein: a dampening mechanism for the soxRS redox stress response.

Journal of bacteriology ·Vol. 175 ·No. 22 ·1993-11-00 ·Pages 7492-4

Nunoshiba T, Hidalgo E, Li Z, Demple B

Abstract

The soxRS redox stress regulon of Escherichia coli is triggered in two stages, with the activated SoxR protein stimulating the soxS gene, whose product then triggers transcription of approximately 10 promoters. Genetic and biochemical experiments presented here show that SoxS protein also limits soxS transcription in vivo and binds the soxS promoter in vitro.

MeSH Terms

Bacterial Proteins/biosynthesis,genetics,metabolism Escherichia coli/genetics,metabolism Escherichia coli Proteins Gene Expression Regulation, Bacterial Genes, Bacterial Kinetics Oxidation-Reduction Recombinant Fusion Proteins/biosynthesis,metabolism Regulon Restriction Mapping Trans-Activators Transcription Factors/biosynthesis,genetics,metabolism beta-Galactosidase/biosynthesis,metabolism

Chemicals

Bacterial Proteins Escherichia coli Proteins Recombinant Fusion Proteins Trans-Activators Transcription Factors SoxS protein, E coli beta-Galactosidase

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Nunoshiba T

Department of Molecular and Cellular Toxicology, Harvard School of Public Health, Boston, Massachusetts 02115.

Hidalgo E

Li Z

Demple B

References (12)

12 references, click to expand

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A global response induced in Escherichia coli by redox-cycling agents overlaps with that induced by peroxide stress.
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soxR, a locus governing a superoxide response regulon in Escherichia coli K-12.
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Positive control of a global antioxidant defense regulon activated by superoxide-generating agents in Escherichia coli.
Proc Natl Acad Sci U S A. 1990 Aug;87(16):6181-5 PMID: 1696718
Two divergently transcribed genes, soxR and soxS, control a superoxide response regulon of Escherichia coli.
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Potent intracellular oxidative stress exerted by the carcinogen 4-nitroquinoline-N-oxide.
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Redox redux: the control of oxidative stress responses.
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Fumarase C, the stable fumarase of Escherichia coli, is controlled by the soxRS regulon.
Proc Natl Acad Sci U S A. 1992 Jul 1;89(13):5892-6 PMID: 1631070
Two-stage control of an oxidative stress regulon: the Escherichia coli SoxR protein triggers redox-inducible expression of the soxS regulatory gene.
J Bacteriol. 1992 Oct;174(19):6054-60 PMID: 1400156
Posttranscriptional repression of Escherichia coli OmpF protein in response to redox stress: positive control of the micF antisense RNA by the soxRS locus.
J Bacteriol. 1993 Feb;175(4):1026-31 PMID: 7679383
Molecular characterization of the soxRS genes of Escherichia coli: two genes control a superoxide stress regulon.
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Article Info

Journal

Journal of bacteriology

Abbr.

J Bacteriol

ISSN

0021-9193

DOI

10.1128/jb.175.22.7492-7494.1993

Published

1993-11-00

Pages

7492-4

Language

English

Region

United States

NLM ID

2985120R

PMCID

PMC206898

Subset

Grants

NCI NIH HHS · CA37831 · United States

External Links

PubMed source DOI: 10.1128/jb.175.22.7492-7494.1993 PMC Full Text View journal details

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Negative autoregulation by the Escherichia coli SoxS protein: a dampening mechanism for the soxRS redox stress response.

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