Biochemical characterization of the human carbonic anhydrase variant CA Ih Hiroshima.

Human genetics ·Vol. 34 ·No. 1 ·1976-09-10 ·Pages 29-34

Tanis RJ, Osborne WR, Ueda N, Tashian RE

Abstract

Some biochemical properties of a new red cell human carbonic anhydrase variant, CA Ih Hiroshima, have been determined. Evidence is presented that the amino acid substitution in the Japanese variant is not the same as the previously characterized CA Ic variant from Guam of similar electrophoretic mobility. Based on a comparison with the normal CA I isoenzyme, a proposal for the site of the amino acid substitution is presented.

MeSH Terms

Amino Acid Sequence Carbonic Anhydrases/analysis,blood Drug Stability Genetic Variation Hot Temperature Humans Japan Peptides/analysis Protein Conformation Spectrophotometry

Chemicals

Peptides Carbonic Anhydrases

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Tanis R J

Osborne W R

Ueda N

Tashian R E

References (13)

13 references, click to expand

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Article Info

Journal

Human genetics

Abbr.

Hum Genet

ISSN

0340-6717

DOI

10.1007/BF00284431

Published

1976-09-10

Pages

29-34

Language

English

Region

Germany

NLM ID

7613873

Subset

External Links

PubMed source DOI: 10.1007/BF00284431 View journal details

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Biochemical characterization of the human carbonic anhydrase variant CA Ih Hiroshima.

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