New assay of protective activity of Rocky Mountain spotted fever vaccines.

Journal of clinical microbiology ·Vol. 4 ·No. 3 ·1976-09-00 ·Pages 309-11

Anacker RL, Smith RF, Mann RE, Hamilton MA

Abstract

Areas under the fever curves of guinea pigs inoculated with Rocky Mountain spotted fever vaccine over a restricted dose range and infected with a standardized dose of Rickettsia rickettsii varied linearly with log10 dose of vaccine. A calculator was programmed to plot fever curves and calculate the vaccine dose that reduced the fever of infected animals by 50%.

MeSH Terms

Animals Body Temperature Drug Evaluation, Preclinical Guinea Pigs Injections, Intraperitoneal Male Rickettsia rickettsii/immunology Rickettsial Vaccines/administration & dosage Rocky Mountain Spotted Fever/prevention & control Vaccines/administration & dosage

Chemicals

Rickettsial Vaccines Vaccines

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Anacker R L

Smith R F

Mann R E

Hamilton M A

References (6)

6 references, click to expand

Factors affecting the growth of rickettsias of the spotted fever group in fertile hens' eggs.
J Infect Dis. 1962 Mar-Apr;110:121-8 PMID: 13917322
Spotted fever vaccine; potency assay by direct challenge of vaccinated mice with toxin of Rickettsia rickettsii.
J Immunol. 1961 Dec;87:737-46 PMID: 13866804
A toxic substance associated with the rickettsias of the spotted fever group.
J Immunol. 1953 May;70(5):461-72 PMID: 13052922
Immunization against scrub typhus. II. Preparation of lyophilized living vaccine.
Am J Hyg. 1951 May;53(3):326-31 PMID: 14829444
Purification of Rickettsia rickettsi by density-gradient zonal centrifugation.
Can J Microbiol. 1974 Nov;20(11):1523-7 PMID: 4215550
Immunological properties of Rickettsia rickettsii purified by zonal centrifugation.
Infect Immun. 1975 Jun;11(6):1203-9 PMID: 806522

Article Info

Journal

Journal of clinical microbiology

Abbr.

J Clin Microbiol

ISSN

0095-1137

DOI

10.1128/jcm.4.3.309-311.1976

Published

1976-09-00

Pages

309-11

Language

English

Region

United States

NLM ID

7505564

PMCID

PMC274455

Subset

External Links

PubMed source DOI: 10.1128/jcm.4.3.309-311.1976 PMC Full Text View journal details

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