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PMID: 823563 Published · ppublish English Clinical Trial Controlled Clinical Trial Journal Article Randomized Controlled Trial

The effect of minor tranquilizers on psychomotor performance.

Psychopharmacology ·Vol. 47 ·No. 3 ·1976-06-23 ·Pages 281-6

Wittenborn JR, Flaherty CF, Hamilton LW, Schiffman HR, McGough WE

Abstract

The effect of a standard daily regimen of chlordiazepoxide, prazepam (a new benzodiazepine tranquilizer), and placebo were examined in a three way double-blind comparison for a sample of normal volunteers. The criteria include a limited spectrum of psychomotor functions. A learning effect was conspicuous for all drugs on all criteria during the day-long sequence of ten trials. For the most part the differences between the drug groups were insignificant, but there were distinctive modifications in the performance of the chlordiazepoxide group. The clearest effect of the tranquilizer medications was found in the time estimation tests. Paradoxically, the drugs correct a naturally occurring perceptual error.

MeSH Terms
Adult Chlordiazepoxide/pharmacology Humans Male Motor Skills/drug effects Prazepam/pharmacology Psychomotor Disorders/chemically induced Time Perception/drug effects
Chemicals
Chlordiazepoxide Prazepam
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Wittenborn J R
Flaherty C F
Hamilton L W
Schiffman H R
McGough W E
References (11)
11 references, click to expand
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Article Info
Journal
Psychopharmacology
Abbr.
Psychopharmacology (Berl)
ISSN
0033-3158
DOI
10.1007/BF00427614
Published
1976-06-23
Pages
281-6
Language
English
Region
Germany
NLM ID
7608025
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00427614 View journal details
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