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PMID: 8248213 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

"BFA bodies": a subcompartment of the endoplasmic reticulum.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 90 ·No. 23 ·1993-12-01 ·Pages 11089-93

Orci L, Perrelet A, Ravazzola M, Wieland FT, Schekman R, Rothman JE

Abstract

A specialized region of the endoplasmic reticulum--the BFA body--is defined by the site of accumulation of coatomer when nonclathrin coat protein (COP)-coated vesicle assembly is prevented by the drug brefeldin A (BFA). BFA bodies are formed by part smooth, part rough domains of endoplasmic reticulum that are cis to the classical transitional endoplasmic reticulum and to BFA-induced Golgi remnants.

MeSH Terms
Animals Brefeldin A Coatomer Protein Cyclopentanes/pharmacology Endoplasmic Reticulum/ultrastructure Golgi Apparatus/ultrastructure Immunohistochemistry Intracellular Membranes/ultrastructure Islets of Langerhans/ultrastructure Membrane Proteins/metabolism Microscopy, Electron Microtubule-Associated Proteins/metabolism Rats
Chemicals
Coatomer Protein Cyclopentanes Membrane Proteins Microtubule-Associated Proteins Brefeldin A
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Orci L
Department of Morphology, University of Geneva Medical School, Switzerland.
Perrelet A
Ravazzola M
Wieland F T
Schekman R
Rothman J E
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.90.23.11089
Published
1993-12-01
Pages
11089-93
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC47927
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.90.23.11089 PMC Full Text View journal details
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