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PMID: 8248239 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

A receptor for interleukin 10 is related to interferon receptors.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 90 ·No. 23 ·1993-12-01 ·Pages 11267-71

Ho AS, Liu Y, Khan TA, Hsu DH, Bazan JF, Moore KW

Abstract

We isolated cDNAs encoding a mouse interleukin 10 receptor (mIL-10R) from mouse mast cell and macrophage cell lines. The two cDNAs are substantially identical and express an approximately 110-kDa polypeptide in COS7 cells, which binds mIL-10 specifically. A mouse pro-B-cell line (Ba/F3) expressing transfected recombinant mIL-10R binds IL-10 with high affinity (approximately 70 pM) and proliferates in response to mIL-10. mIL-10R is structurally related to interferon receptors (IFNRs). Since IL-10 inhibits macrophage activation by IFN-gamma, a possible implication of this relationship interaction of IL-10R and IFN-gamma R or their signaling pathways.

MeSH Terms
Amino Acid Sequence Animals Cell Division Cloning, Molecular DNA Primers/chemistry DNA, Complementary/genetics Gene Expression Mice Molecular Sequence Data RNA, Messenger/genetics Receptors, Interferon/chemistry Receptors, Interleukin/chemistry Receptors, Interleukin-10 Sequence Alignment Sequence Homology, Amino Acid Signal Transduction Transfection
Chemicals
DNA Primers DNA, Complementary RNA, Messenger Receptors, Interferon Receptors, Interleukin Receptors, Interleukin-10
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Ho A S
Department of Immunology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304.
Liu Y
Khan T A
Hsu D H
Bazan J F
Moore K W
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.90.23.11267
Published
1993-12-01
Pages
11267-71
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC47963
Subset
IM
Databases
GENBANK
L12120
External Links
PubMed source DOI: 10.1073/pnas.90.23.11267 PMC Full Text View journal details
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