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PMID: 825106 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Evolution of mammalian carbonic anhydrase loci by tanden duplication: close linkage of Car-1 and Car-2 to the centromere region of chromosome 3 of the mouse.

Biochemical genetics ·Vol. 14 ·No. 7-8 ·1976-08-00 ·Pages 651-60

Eicher EM, Stern RH, Womack JE, Davisson MT, Roderick TH, Reynolds SC

Abstract

Electrophoretic variants of two carbonic anhydrase enzymes CAR-1 (CA I) and Car-2 (CA II), have been found in the laboratory mouse, Mus musculus. These two loci are closely linked to each other and are located on chromosome 3 near its centromere. The close linkage of Car-1 and Car-2 supports the hypothesis that the present-day carbonic anhydrase loci are the result of tandem duplication of an earlier carbonic anhydrase locus with subsequent divergence. The red blood cells of mice of the subspecies M.m. casteneus have significantly reduced levels of CAR-1 and CAR-2.

MeSH Terms
Alleles Animals Carbonic Anhydrases/blood Chromosomes Crosses, Genetic Erythrocytes/enzymology Female Genetic Linkage Genetic Variation Isoenzymes/blood Male Mice Mice, Inbred Strains Phenotype Species Specificity
Chemicals
Isoenzymes Carbonic Anhydrases
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Eicher E M
Stern R H
Womack J E
Davisson M T
Roderick T H
Reynolds S C
References (10)
10 references, click to expand
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Article Info
Journal
Biochemical genetics
Abbr.
Biochem Genet
ISSN
0006-2928
DOI
10.1007/BF00485843
Published
1976-08-00
Pages
651-60
Language
English
Region
United States
NLM ID
0126611
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00485843 View journal details
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