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PMID: 8256851 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Is the "preamyloid" of diffuse plaques in Alzheimer's disease really nonfibrillar?

The American journal of pathology ·Vol. 143 ·No. 6 ·1993-12-00 ·Pages 1594-605

Davies CA, Mann DM

Abstract

Several papers have described an 'amorphous' component of the amyloid in diffuse plaques and it has been suggested that this is 'preamyloid,' which is not organized into fibrils. Because most of the studies have been performed on autopsy tissue it was the purpose of this study to compare the ultrastructure of diffuse amyloid deposits in well preserved Alzheimer's disease biopsy specimens with autopsy tissues from patients with Alzheimer's disease and Down's syndrome. A postembedding immunogold technique with anti-beta/A4 protein demonstrated gold particles exclusively on extracellular amyloid fibrils in both biopsy and autopsy brains. We have presented evidence that suggests the claim for the existence of an amorphous component within the beta/A4 protein-positive material is unconvincing.

MeSH Terms
Aged Alzheimer Disease/metabolism,pathology Amyloid beta-Protein Precursor/analysis,metabolism,ultrastructure Autopsy Biopsy Cerebral Cortex/chemistry,pathology,ultrastructure Down Syndrome/metabolism,pathology Humans Microscopy, Electron Microscopy, Immunoelectron Middle Aged Neurofibrillary Tangles/chemistry,metabolism,ultrastructure
Chemicals
Amyloid beta-Protein Precursor
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Davies C A
Department of Pathological Sciences, University of Manchester, United Kingdom.
Mann D M
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33 references, click to expand
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Article Info
Journal
The American journal of pathology
Abbr.
Am J Pathol
ISSN
0002-9440
Published
1993-12-00
Pages
1594-605
Language
English
Region
United States
NLM ID
0370502
PMCID
PMC1887266
Subset
IM
Corrections
CommentIn
PMID: 7887458
External Links
PubMed source PMC Full Text View journal details
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