Purification of a plasminogen activator inhibitor indistinguishable from alpha1-antitrypsin and an urokinase inhibitor in pregnancy plasma.

Haemostasis ·Vol. 5 ·No. 4 ·1976-00-00 ·Pages 218-30

Clemmensen I, Thorsen S, Müllertz S

Abstract

An inhibitor of urokinase present in increased concentrations in plasma during pregnancy was purified. The inhibitor was identified by its pronounced effect on urokinase-induced fibrinolysis as opposed to the absence of effect on fibrinolysis induced by a tissue plasminogen activator. The inhibitor progressively inactivated urokinase upon incubation and was found to be indistinguishable from alpha1-antitrypsin.

MeSH Terms

Antithrombins/isolation & purification Chemical Fractionation Chromatography, Gel Female Fibrinolysis/drug effects Humans Male Plasma/analysis Plasminogen Activators/antagonists & inhibitors Plasminogen Inactivators Pregnancy Protease Inhibitors Urokinase-Type Plasminogen Activator/antagonists & inhibitors,pharmacology alpha 1-Antitrypsin/isolation & purification,pharmacology

Chemicals

Antithrombins Plasminogen Inactivators Protease Inhibitors alpha 1-Antitrypsin Plasminogen Activators Urokinase-Type Plasminogen Activator

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Clemmensen I

Thorsen S

Müllertz S

Article Info

Journal

Haemostasis

Abbr.

Haemostasis

ISSN

0301-0147

DOI

10.1159/000214137

Published

1976-00-00

Pages

218-30

Language

English

Region

Switzerland

NLM ID

0371574

Subset

External Links

PubMed source DOI: 10.1159/000214137

Analysis Services

Purification of a plasminogen activator inhibitor indistinguishable from alpha1-antitrypsin and an urokinase inhibitor in pregnancy plasma.

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